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  • 1.  About articles

    Posted 02-19-2020 21:35
    Hi everyone,
    I am new here. Recently, I really get into toxicology but I am having trouble with finding articles online. Do you have any suggestions? Especially, cosmetic kinds of stuff such as ingredients testing for toxicology. ER bioactivity, ToxCast etc..

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    Enkhtsetseg Boldbaatar CSP
    Arlington VA
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  • 2.  RE: About articles

    SENIOR MEMBER
    Posted 02-20-2020 13:53
    Hi, Enkhtsetseg.  I have spent a fair amount of my career finding ways to fold toxicity information along with physical property data into tools that provide a screening-level assessment of potential for harm, so that facilities can prioritize the substances and processes that they want to spend time finding substitutes or reduction measures for.

    The US has the IRIS database, but it barely has any substances in it.  There are excel files of harmonized list of substances (GHS assignments) that have hazard statements and hazard categories, with levels of hazard for various health and environmental effects.  However, these lists only contain a few thousand substances, and while that might seem like a lot, my personal experience has been that on the factory floor about a third to a half of the substances being used don't appear in the harmonized lists.   I imagine that cosmetic ingredients are the same.  One example of a spreadsheet compilation of hazard evaluations is the Australian one at http://hcis.safeworkaustralia.gov.au/HazardousChemical.  Hit the search button without filling it in and then download the Excel file version.

    For very detailed information about toxicity and for a broader set of substances than appear in the harmonized lists, you might find the European Chemicals Agency registered substances data base useful.  It is at https://www.echa.europa.eu/web/guest/information-on-chemicals/registered-substances

    This data base has a lot of info that is easy to miss.  I will walk you through the process of finding info on butylated hydroxyanisole, a preservative that is found in cosmetics.   Maybe there are quicker ways to find the info, I dunno.

    Open the above link, put the substance name (in this case butylated hydroxyanisole) into the substance name field, and hit the search button.   Towards the bottom of the screen you will see the search results.  In this case, only one search result is found, for tert-butyl-4-methoxyphenol, which is a synonym for butylated hydroxyanisole.  Click on the link for this entry, which opens up an "infocard."  Up at the top you can see that this substance has a warning:  " Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is toxic to aquatic life with long lasting effects, causes serious eye irritation, is suspected of causing cancer, is suspected of damaging fertility or the unborn child, is harmful if swallowed and causes skin irritation."  It also says that the substance is under investigation for being an endocrine disruptor.   Next to the printer icon there is an icon that says "BP," for "brief profile," click on that.  Click on the "scientific properties" tab and then for this example scroll way down to "toxicity to reproduction" and click on the little arrow that points up and to the right, next to the question mark icon.  That takes you to the REACH dossier that was used to develop the toxicity assignments.   Under "toxicity to reproduction" in the bar on the left hand side of the screen there are two choices besides endpoint summary.  Again, just for example, let's pick "Developmental toxicity / teratogenicity."  There's a drop down menu that lets you select each of the references that were used in the REACH dossier and gives the results from that reference.

    I hope this helps you get started.   I don't mind going into more detail about any of this, if necessary.



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    -Kirsten

    Kirsten Rosselot
    Process Profiles
    Calabasas, CA United States
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  • 3.  RE: About articles

    Posted 02-20-2020 23:17
    Hi Kristen Rosselot, thank you so much! it was perfect. I am so happy to make a post in the discussion center. Your response is perfect for now, I will explore a little further by this.
    Thank you again for your time and your kindness.

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    Enkhtsetseg Boldbaatar CSP
    Arlington VA
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  • 4.  RE: About articles

    SENIOR MEMBER
    Posted 02-21-2020 07:51
    Chemical Engineering Progress has published two articles on the basics of toxicology:

    Toxicology 101
    NOVEMBER, 2015
    CHRISTIN GRABINSKI
    Every substance can be toxic, depending on the dose and frequency of exposure. This article outlines the basics of toxicology and explores where the research in this field is heading.
    https://www.aiche.org/resources/publications/cep/2015/november/toxicology-101


    A ChE's Guide to Toxicology
    JUNE 2004
    LISA M. SWEENEY
    Toxicology impacts a chemical engineer in a variety of ways. Here's what you need to know about the basics of this field.
    https://www.aiche.org/resources/publications/cep/2004/june/ches-guide-toxicology

    As a member of AIChE, you can download both of those from the CEP website.

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    Cynthia Mascone
    Senior Director of Publications and Editor-in-Chief, CEP
    AIChE
    cyntm@aiche.org
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  • 5.  RE: About articles

    SENIOR MEMBER
    Posted 02-21-2020 12:09
    While I don't have specific answers for you, I suggest you check out the Society of Cosmetic Chemists.  I was a member until retirement and found they had/have a wealth of useful information on various topics that may suit your needs.     https://www.scconline.org/

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    Raymond] [Cline]
    [Retired]
    [Fernandina Beach] [FL]
    Raymond
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