I began my undergraduate studies in Molecular and Cellular Biology with a focus on Microbiology in 2011. After graduation, while pursuing a master's degree in collection of Biotechnology and Pharmaceutical with a focus on Pharmaceutical Engineering (M.Pharm.Eng) at the University of Tehran, I started my research activities and joined the Iranian Scientific and Industrial Research Organization. I conducted my master's thesis at the Pasteur Institute of Iran the Production and Research Complex, focusing on the design and optimization of production, extraction, and purification systems for proteins from microorganisms as biomass for vaccine adjuvant production.
Over seven years of study and beyond, I acquired extensive industrial and laboratory skills across various fields, including biochemistry, serology, hormone analysis, microbiology, hematology, pathology, pharmaceutical formulation, cosmetics and detergent production, quality control, quality assurance, and different aspects of the pharmaceutical, biopharmaceutical, and phytopharmaceutical industries. I gained expertise in sterile and non-sterile operations, R&D, manufacturing, and the use of pharmaceutical and laboratory equipment, adhering to GMP standards.
Simultaneously, I enhanced my proficiency in machine learning and statistical methods, including MATLAB, MINITAB, time series analysis, regression modeling, hypothesis testing, design of experiments (DOE), and multi-criteria decision-making.
In 2019, after completing my master's degree, I joined the Army Hospital of the Islamic Republic of Iran as a research associate during the COVID-19 pandemic. Concurrently, I conducted research at Tabriz University of Medical Sciences and the Atomic Energy Organization of Iran. During this period, I contributed to drug development and patient treatments, authored multiple international research papers as the corresponding author, and secured several patents.
With achievements in pharmaceutical product development and international honors (Gold medals from Silicon Valley, USA, and the Special Award from Silicon Valley, USA; the Gold Medal of Inventions from Switzerland; the Special Gold Medal for Inventions and Innovations from Germany; the Gold Medal of Inventions from Poland; the Inventions and Innovations Award from the Inventors' Association of China; and gold medals for inventions and innovations from Turkey, Vietnam, the United Arab Emirates, Saudi Arabia, and more) and international awards, I established my pharmaceutical trading company, "NoyanGen Biotechnology Research Company." At the same time, I began my doctoral studies.
Inv. Hamed Aghazadeh
Verification Number ID in IFIA: IR2023AUG1734HXA
Inventor and Researcher | CEO at Knowledge Enterprise Co
Born in 1992, Tabriz, Iran (WikiData)
Education:
* Pharmaceutical Engineering (Collection of Biotechnology and Pharmaceutical)
* Microbiology (Molecular and Cellular Biology)
* Formulations and Manufacture of Cosmetics, Sanitary and Detergents (Chemistry)
* MBA Pharma (Master of Business Administration in Pharmaceutical Management)
* DBA (Doctorate of Business Administration)
Latest Education:
Master of Science, Department of Pharmaceutical Engineering, University of Tehran, Tehran, Iran
Thesis Title:
Designing and Optimization of Production and Purification Process of Mannan from Kluyveromyces marxianus yeast for use as an Vaccine Adjuvant
Supervisors: Dr. Delaram Doroud, Dr. Seyed Nezamedin Hosseini, Dr. Sohrab Ali Ghorbanian
FROM: Pasteur Institute of Iran
Thesis Article Title:
Design of experiment methodology for Mannoprotein Industrial scale manufacturing Bioprocess: Optimization from a yeast cell factory
International Honors and Medals:
M1) GOLD medal and Special Award of ITE International Invention & Trade Expo, Kingston University, London, United Kingdom (October 2025)
- Innovation title: Development and Optimization of Chitosan-Based Nanocomposite Scaffold Reinforced with Magnesium-Doped Hydroxyapatite and Bioactive Agents (Icariin, lithium Chloride and Naringin) for Bone Tissue Regeneration.
- Issued by: Leading British academic institutions including Kingston University, the World Invention Intellectual Property Association (WIIPA) and World Intellectual Property Organization (WIPO).
M2) GOLD medal of ARCA 2025, the 23rd Croatian international innovation exhibition, National University and Library of Zagreb, Zagreb, Croatia (October 2025)
- Innovation title: Title of invention: Selective Small-Molecule Modulator of P2X4 Receptor for Phase-Specific Neuroprotection, Enhanced Phagocytic Clearance, and Neurogenic Recovery in Ischemic Stroke.
- Issued by: Ministry of Science and Research of Croatia, National University of Zagreb and International Federation of Inventors' Associations (IFIA) and World Intellectual Property Organization (WIPO) and University of Zagreb / Sveučilište u Zagrebu.
M3) GOLD Medal and Special Award of the America's SILICON VALLEY International Inventions and Innovations Festival (America's Largest Innovation Exposition USA), Santa Clara, California, USA (Agust 2025)
- Innovation title: Nanoformulation Containing an Exosome-Derived Monoclonal Antibody and a Drug-Binding Ligand Targeting the TfR for Glioblastoma.
- Issued by: Silicon Valley international invention festival (SVIIF) and International Federation of Inventors' Associations (IFIA) and World Intellectual Property Organization (WIPO) and United Inventors Association America (UIA)
M5) GOLD Medal of the 5rd International Competition of Inventions and Innovations (IFIA) in Geneva, Switzerland (August 2025)
- Innovation title: Theranostic Radiolabeled MiniAp-4-Trastuzumab Bioconjugate for Precision Targeting of HER2-Overexpressing Cerebral Metastases
- Issued by: International Federation of Inventors' Associations (IFIA) and World Intellectual Property Organization (WIPO)
M6) Special GOLD medal from the international trade fair, ideas inventions and new products iENA, Nuremberg, Germany (October 2024)
- Innovation title: Production of recombinant protein that inhibits cancer stem cells
- Issued by: International Federation of Inventors' Associations (IFIA), International Trade fair of ideas and new products (iENA) and World Intellectual Property Organization (WIPO)
M7) GOLD Medal of the 4rd International Competition of Inventions and Innovations (IFIA) in Geneva, Switzerland (August 2024)
- Innovation title: Demodex and Sarcoptes anti-parasite medicine (Anti-scabie drug)
- Issued by: International Federation of Inventors' Associations (IFIA) and World Intellectual Property Organization (WIPO)
M8) GOLD Medal & Special Medal of the America's SILICON VALLEY International Inventions and Innovations Festival (America's Largest Innovation Exposition USA), Santa Clara, California, USA (July 2024)
- Innovation title: Lung Cancer Antibody Production
- Issued by: Silicon Valley international invention festival (SVIIF) and International Federation of Inventors' Associations (IFIA) and World Intellectual Property Organization (WIPO) and United Inventors Association America (UIA)
M9) GOLD medal & Special Award (International of Innovative and Trade London) of Saudi global Invention and Innovations Expo (SGiE), Jeddah, Saudi Arabia 2024
- Innovation title: AI Revolution in Oncology: Advanced Cancer Detection and Treatment
- Issued by: World Invention Intellectual Property associations (WIIPA) and World Intellectual Property Organization (WIPO), Highly Innovative Unique Foundation (HIUF) and International of Innovative and Trade London
M10) GOLD medal of UAE global Invention and Innovations (DIS EXPO Dubai), Dubai, UAE 2024
- Innovation title: HOCL Nanoparticle Drug Delivery System For Cancer Cells
- Issued by: World Invention Intellectual Property associations (WIIPA) and World Intellectual Property Organization (WIPO)
Publications:
P1) Synthesis of MnO3/CdTiO3 nano-structure for high performance photocatalysis and antimicrobial application.
- Publisher: Wiley, Applied Organometallic Chemistry
P2) miR-193a-5p serves as a promising therapeutic candidate in colorectal cancer by reducing 5-FU and Oxaliplatin chemoresistance via targeting CXCR4
- Publisher: Elsevier, International ImmunoPharmacology
P3) Design and Production of DNA-Based Electrochemical and Biological Biosensors for the Detection and Measurement of Gabapentin Medication in Clinical Specimens
- Publisher: IOPscience, Journal of The Electrochemical Society (JES)
P4) Microencapsulation of herbal bioactive drug by Chlorella vulgaris microalgae as a nano-formulation for drug delivery to cells
- Publisher: Journal of Medicinal and Pharmaceutical Chemistry Research
P5) Vancomycin prolonged release via PLGA system loaded with drug-containing chitosan nanoparticles as a novel in situ forming drug delivery system
- Publisher: Journal of Medicinal and Pharmaceutical Chemistry Research
P6) An herbal bioactive drug compound with a delayed release curve in PEGylated cationic nano-niosomes formulation for cancer cells
- Publisher: Elsevier, Biocatalysis and Agricultural Biotechnology
P7) A novel herbal medicine formulation with potential anti-scabies properties to treat Demodex and Sarcoptes parasites
- Publisher: Razi Vaccine & Serum Research Institute, Archives of Razi Institute
P8) Chemical Composition, Antioxidant Properties, and Antimicrobial Activity of Ferula assa-foetida L. Essential Oil against Pathogenic Bacteria
- Publisher: Chemical Methodologies
P9) Use genetic modification indicator to increase the precision and accuracy of genomic analysis
- Publisher: National Documentation Centre (EKT), Journal of the Hellenic Veterinary Medical Society (J Hellenic Vet Med Soc)
P10) Exploring the Intricacies of Cervical Intraepithelial Neoplasia and its Connection with HPV: A Comprehensive Review
- Publisher: Iranian Journal of Public Health, Tehran University of Medical Sciences,
P11) Design of experiment methodology for Mannoprotein Industrial scale manufacturing Bioprocess: Optimization from a yeast cell factory
- Publisher: Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
P12) Expression Level of MicroRNA-122 in Serum Samples of Patients with Atherosclerosis
- Publisher: Acta Medica Iranica, Tehran University of Medical Sciences
P13) The effect of Bifidobacterium Longum on the Expression Level of Hfq in Escherichia Coli O157:H7
- Publisher: The Iranian Society of Microbiology, Iranian Journal of Medical Microbiology
P14) Electrospun Scaffold with L-Arginine and Hydroxyapatite Nanoparticles for Periodontitis Therapy
- Publisher: Springer Nature, Emergent Materials
Inventions & Patents:
P1) Patent Registration: Bone Infection (Osteomyelitis) Drug Delivery System (Official registration code that can be verified for this product/invention: B0F65M9796)
FROM: United States of America
P2) Manufacturing of Bone Infection (Osteomyelitis) Drug Delivery System (PAT NO: 105935)
FROM: Iran Patent Office [Iran Nanotechnology Innovation Council & Iranian Research Organization for Science and Technology (IROST)]
P3) Manufacturing of Fully Automatic Health Monitoring Device for Vital Signs (PAT NO: 107658)
FROM: Iran Patent Office [University of Tabriz]
P4) Manufacturing of Anti-Parasitic Drug Against Demodex and Sarcoptes (Anti-Scabies Medicine) (PAT NO: 107091)
FROM: Iran Patent Office [Tabriz University of Medical Sciences]
P5) Extraction of effective anti-cancer medicinal substances using nanotechnology for pharmaceutical applications (PAT NO: 108919)
FROM: Iran Patent Office [Chemistry & Chemical Engineering Research Center of Iran (CCERCI)]
P6) The intelligent system for monitoring the user's ergonomic status and behavior (PAT NO: 109365)
FROM: Iran Patent Office [Ministry of Information and Communications Technology of Iran (ICT Research Institute)]
P7) Ultrafiltration membrane modified for medicinal and microbial applications (PAT NO: 11014)
FROM: Iran Patent Office [East Azarbaijan Science and Technology Park]
P8) Production of cancer-specific antibodies as a targeted nanodrug (PAT NO: 112452)
FROM: Iran Patent Office [Iran Nanotechnology Innovation Council (INIC)]
Books:
B1) Bone infection drug delivery system
Publisher: Amazon, USA (Amazon Standard Identification Number ASIN: B0DHGBPNTZ , ISBN: 979-8339620266)
B2) Adjuvant by Processing of Mannan (from Kluyveromyces marxianus Yeast)
Publisher: National Library of Iran
B3) Ionically Gelled Biopolysacarid Basic System in Drug Delivery
Publisher: National Library of Iran
B4) Recombinant Proteins Production using Engineered Yeasts
Publisher: National Library of Iran
B5) Good Operational Engineering for GMP Pharmaceutical Site and GLP Laboratory Processes
Publisher: National Library of Iran
B6) Gene expression levels in Atherosclerosis patients
Publisher: National Library of Iran
B7) Treatment methods of intestinal infection with probiotics
Publisher: National Library of Iran
B8) The Application of Ai in the Diagnosis of Liver Cancer
Publisher: Amazon, USA (Amazon Standard Identification Number ASIN: B0DGCXW47P , ISBN: 979-8338480823)
B9) AI Revolution in Oncology
Publisher: Supreme Century, USA (ISBN-10: 1939123860 , ISBN-13: 978-1939123862)
B10) Liver Cancer in Individuals with High Cortisol Levels
Publisher: Amazon, USA (Amazon Standard Identification Number ASIN: B0F24L31BN , ISBN: 979-8314959275)
B11) Intelligent Scaffolds for Advanced Bone Regeneration
Publisher: Heritage Branch, Library and Archives Canada (ISBN-10: 1069324388 , ISBN-13: 978-1069324382)
B12) Hemostasis and Fibrinolytic Enzyme Secretory Microorganisms
Publisher: Heritage Branch, Library and Archives Canada (ISBN-10: 1069324396 , ISBN-13: 978-1069324399)
B13) Development of a Bioactive Nanocomposite Using 3D Printing for Bone Tissue Engineering Applications with Targeted Drug Delivery
Publisher: Scholars' Press, USA (ISBN-10: 6200696160 , ISBN-13: 978-6200696168)
B14) Precision Chronotherapy: AI and Personalized Treatment for Neurodegenerative Circadian Disorders
Publisher: Scholars' Press, USA (ISBN-10: 6138265211 , ISBN-13: 978-6138265214)
B15) Advances in Precision Theranostics for HER2-Positive Brain Metastases
Publisher: Scholars' Press, USA (ISBN-10: 613839514X , ISBN-13: 978-6138395140)
B16) Nanoformulation Containing an Exosome-Derived Monoclonal Antibody: and a Drug-Binding Ligand Targeting the Transferrin Receptor (TfR) for Glioblastoma
Publisher: Scholars' Press, USA (ISBN-10: 6138395395 , ISBN-13: 978-6138395393)
B17) ARIA-NET: Adaptive Real-Time Imaging Analytics for Neurological Emergency Triage
Publisher: Scholars' Press, USA (ISBN-10: 6209133983 , ISBN-13: 978-6209133985)
B18) Neuroprotection and Regeneration in Stroke the Role of P2X4 Small-Molecule Modulators
Publisher: Scholars' Press, USA (ISBN-10: 6209136540 , ISBN-13: 978-6209136542)
B19) Regenerative Periodontology and Implantology 3D-Printed Nanocomposite Scaffolds with Dual Drug Delivery
Publisher: Scholars' Press, USA (ISBN-10: 6209136583 , ISBN-13: 978-6209136580)
Research and Academic Skills:
1) Laboratory Skills: [Dissolution Testing, UV/Vis Spectroscopy, FTIR, Raman Spectroscopy, Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), Enzyme assay and analysis, Polymerase Chain Reaction (PCR), Powder X-ray Diffraction, DPPH, HPLC, GC-MAS, Fermentation, Formulation, Extraction, Bacterial and Cell Culture]
2) Analytical Skills: [IBM Statistics, Design of experiment (DOE), Scientific Analysis, Research, Taguchi Method, Optimization Methods, Minitab, Good Laboratory Practice (GLP), Good manufacturing practice (GMP)]
Skills and Courses:
1. Production of Cosmetics, Sanitary and Detergents (Golrang Industrial Group).
2. Tissue Engineering & Principle of cell Culture (2d Culture, MTT Assay, Stem Cell Culture, Cell Differentiation).
3. Industrial Pharmacy Courses.
4. Bioinformatics
5. Pharmaceutical Quality Management.
6. Analysis of Chromatography Device (High Performance Liquid Chromatography and Gass Chromatography).
7. Formulation and Design of Drug Delivery System
8. Designing and Modeling Drugs and Vaccines.
9. Extraction and Purification of Active Pharmaceutical Ingredients.
10.Commercialization and Intellectual Property in the Pharmaceutical Industry.
11. Culture of Urine, Feces and Blood.
12. Orientation and How to work in the Clean rooms.
13. DNA and RNA Extraction and Purification.
14. Analysis and Creation of Animal Methods of Cancer.
15. Cellular Therapy (CT).
16. Protein Modeling.
17. Drug Delivery by Nanoparticles.
18. Molecular Genetics Lab Techniques.
19. Cancer Cell Detection and Isolation.
20. Analysis and Data Visualization in R and Python.
21. ELISA and PCR.
22. Medical Diagnostic Laboratory Technician.
23. Drug Design.
24. Flow Cytometry.
25. Cell Culture.
26. Medical Laboratory Technician.
27. Pharmacy Technician.
28. Vaccine Design and Production.
29. Monoclonal Antibody Production.
30. Genetic Engineering.
31. Fermentation.
32. Extraction and Industrial Purification of Essential Oils and Plant Extracts.
RESEARCH INTERESTS:
The principal research focusis Drug Delivery and Nanomedicine including :
Smart polymers: Synthesis and application in drug delivery systems.
Biodegradable polymeric nanoparticles: Synthesis and usesin diseases targeted drug delivery systems focus on cancer therapy and diagnosis.
Novel nanobiomaterials: synthesis and use in tissue engineering and regenerative medicine.
Natural hydrogels: fabrication for wound-healing applications
Domestic Honors and Awards (Iranian):
H1) Distinguished Researcher at the Military Hospital
- Issued by: Iranian Military Hospital (Army Health Administration)
H2) Provincial Award for Science and Technological Innovation
- Issued by: Tabriz University of Medical Sciences
H3) Obtaining the approval of Iran's National Elite Foundation for the invention of Manufacturing an antiparasitic drug against Demodex and Sarcoptes (anti-scab drug)
- Issued by: Iran's National Elites Foundation . . . بنیاد ملی نخبگان
International Technical and Vocational Courses and Certificates:
1. Pilot PPL & CPL levels.
2. Search Engine Optimization (SEO) & Programming (Python, Delphi, C++) & Web Developer & Generative Pre-trained Transformer 4 (GPT4).
3. Relief (Technical).
4. International Specialized Scientific and Practical Courses of the Red Crescent (Rescuer, Relief, Pre-Hospital, Road Operations, Mountain operations).
5. Installation of security and protection systems (Smart Home & ... ).
6. Support and repair of laboratory equipment and CSR Sterilizers.
7. ICDL 1 & 2.
8. Industrial Electronics
9. Search Engine Optimization (SEO) & Programming (Python, Delphi, C++) & Web Developer
10. Artificial intelligence: Generative Pre-trained Transformer 4 (GPT4)
11. Advisor and instructor of Cryptocurrency (Crypto Assets) , Privacy coin, Stable coin, Exchange crypt, Platform coins & … for real and legal companies.
International Public Courses and Certifications:
- Pilot Courses (PPL & CPL levels)
- Skydiving (parachute), AFF level
- Diving (Amateur)
Associations & Membership:
- American Electrochemical Society
United States of America
- International Society for Pharmaceutical Engineering
United States of America
- IFIA Inv-Member (International Federation of Inventors Associations Member; Verification Number ID: IR2023AUG1734HXA)
Swiss
- Iran’s National Elites Foundation
Islamic Republic of Iran
- Young Researchers and Elite Club (Researcher ID: 3982281020135)
Islamic Republic of Iran
Email:
Hamed.Aghazadeh@ut.ac.ir
Hamed.Aghazadeh860@gmail.com
HamedAghazadeh@ymail.com